Metformin as an Anticancer Drug: A Commentary on the Potential Therapeutic Strategy and Underlying Mechanism of Metformin in Gastric Cancer
نویسنده
چکیده
Metformin therapy is a burst of interest in cancer chemoprevention and therapeutic strategies [1-4]. Epidemiological studies based on cohorts with type 2 diabetes revealed that metformin usage was associated with a reduced risk for various cancer, including breast, colorectal, prostate and pancreas cancers [5]. Meanwhile, the efficacy of cancer chemopreventive effect of metformin has achieved positive results in multiple target organs, especially, colon and mammary cancer [6]. However, only few epidemiological evidences supported the positive link between type2 diabetes and an increased risk of gastric malignancies [5].
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